치유하는 나무의 눈물
매스틱의 효과
고대로부터 사랑받아 온 매스틱의 치유력
이제 현대 의학이 입증했습니다.
전세계의 매스틱 관련 연구 논문
- Balan K.V., Prince J., Han Z., Dimas K., Cladaras M., Wyche J.H., Sitaras N.M., Pantazis P. 2007]: Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia. Phytomedicine, 14 (4):263-272.
- Dimas K., Hatziantoniou S., Wyche J.H., Pantazis P. [2009]: A mastic gum extract induces suppression of growth of human colorectal tumor xenografts in immunodeficient mice. In Vivo, 23 (1): 63-68.
- Nasr M., Saad I.E. [2011]: Formulation and evaluation of mastic gum as a compression coat for colonic delivery of 5-flurouracil. Int. J. Drug Del., 3: 481-491.
- Loutrari H., Magkouta S., Pyriochou A., Koika V., Kolisis F.N., Papapetropoulos A., Roussos C. [2006]: Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. Nutrition and Cancer, 55 (1): 86–93
- Magkouta S., Stathopoulos G.T., Psallidas I., Papapetropoulos A., Kolisis F.N., Roussos C., Loutrari H. [2009]: Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. Nutr Cancer., 61 (5):640-648.
- Moulos P., Papadodima O., Chatziioannou A., Loutrari H., Roussos C., Kolisis F.N. [2009]: A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival. BMC Med Genomics, 15 (2): 68.
- Loutrari H., Magkouta S., Papapetropoulos A., Roussos C. [2011]: Mastic oil inhibits the metastatic phenotype of mouse lung adenocarcinoma cells. Cancers 3: 789-801.
- Park J.H., Kim G.C., Kwak H.H., Kim I.R., Lee S.E., Chung J., Park H.R., Shin S.H., Choi S.H., Kim C.H., Nam C.O., Park B.S. [2008]: Chios Gum Mastic Induces Cell Cycle Arrest and Apoptosis in YD9 Human Oral Squamous Carcinoma Cells. Korean J Phys Anthropol., 21(1): 55-68.
- Min J.H., Kim M.J., Kim I.R., Lee S.E., Kwak H.H., Kim G.C., Park H.R., Shin S.H., Kim C.H., Jeong N.Y., Suh H., Park B.S. [2008]: Apoptotic Effect of Co-Treatment with a Natural Product, Chios Gum Mastic, and a Synthetic Chenodeoxycholic Acid Derivative, HS-1200, on Human Osteosarcoma Cells. Korean J Phys Anthropol., 21 (2):167-180.
- Baek C.J., Heo J.Y., Kim G.C., Kwak H.H., Kim I.R., Lee S.E., Kim C.H., Jeong N.Y., Park B.S. [2008]: Apoptotic Effect of Co-Treatment with a Natural Product, Chios Gum Mastic, and a Proteasome Inhibitor, Lactacystin, on Human Osteosarcoma Cells. Korean J Anat. 41 (2): 129-138.
- Li S., Cha I.H., Nam W. [2011]: Chios Mastic Gum Extracts as a Potent Antitumor Agent that Inhibits Growth and Induces Apoptosis of Oral Cancer Cells. Asian Pac J Cancer Prev., 12 (7): 1877-1880.
- Hur Y.J., Kim Y.K., Kwak H.H., Kim G.C., Lee S.E., Kim I.R., Kim C.H., Park B.S. [2009]: Apoptotic Effect of Co-treatment with Chios Gum Mastic and HS-1200 on G361 Human Melanoma Cell Line. Korean J Anat., 42(2): 83-92.
- Huang X.Y., Wang H.C., Yuan Z., Li A., He M.L., Ai K.X., Zheng Q., Qin H.L. [2010]: Gemcitabine combined with gum mastic causes potent growth inhibition and apoptosis of pancreatic cancer cells. Acta Pharmacol Sin., 31 (6): 741-745.
- He M.-L., Yuan H.-Q., Jiang A.-L., Gong A.Y., Chen W.-W., Zhang P.-J., Young C.Y.F., Zhang J.-Y. [2006]: Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells. Cancer, 106: 2547–2555.
- He M.-L., Li A., Xu C.-S., Wang H.-L., Zhang M.-J., Gu H., Yang Y.-Q., Tao H.-H. [2007]: Mechanisms of antiprostate cancer by gum mastic: NF-?B signal as target. Acta Pharmacologica Sinica, 28 (3): 446-452.
- Spyridopoulou k. Tiptiri-Kourpeti A., Lampiri E., et all [2017]: Dietary mastic oil extracted from Pistacia lentiscus var. Chia suppresses tumor groth in experimental colon cancer models, Scientific Reports 2017; 7: 3782.
- Abdel-Ghaffar A.S., El Nawawy A.S., Mohamed M.S. [1957]: The inhibitory effect of mastic gum on bacterial growth. Alex. Med. J., 3: 119-124.
- Tassou C.C., Nychas G.J.E. [1995]: Antimicrobial activity of the essential oil of mastic gum (Pistacia lentiscus var. chia) on Gram positive and Gram negative bacteria in broth and in model food system. Int. Biodeter. & Biodegr., 36 (3): 411-420.
- Ali-Shtayeh M.S., Abu Ghdeib S.I. [1999]: Antifungal activity of plant extracts against dermatophytes. Mycoses, 42: 665–672.
- Koukoutsis J., Smith J.P., Phillips Daifas D., Yayalan V., Cayouette B., Ngadi M., El-Khoury W. [2004]: Control of Bacillus cereus in high-ph crumpets. J. of Food Safety, 24: 309–324.
- Koukoutsis J., Smith J.P., Phillips Daifas D., Yayalan V., Cayouette B., Ngadi M., El-Khoury W. [2004]: In vitrostudies to control the growth of microorganisms of spoilage and safety concern in high- moisture, high-pH bakery products. J. of Food Safety, 24: 211-230.
- Phillips Daifas D., Smith J.P., Blanchfield B., Sanders G., Austin J.W., Koukoutsis J. [2004]: Effects of mastic resin and its essential oil on the growth of proteolytic Clostridium botulinum. Int. J. of Food Microb. 94 (3): 313– 322.
- Koutsoudaki C., Krsek M., Rodger A. [2005]: Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus var. chia. J. Agric. Food Chem., 53: 7681-7685.
- Al-Habbal M.J., Al-Habbal Z., Huwez F.U. [1984]: A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer. Clin Exp Pharmacol Physiol., 11 (5): 541-544.
- Al-Said M.S., Ageel A.M., Parmar N.S., Tariq M. [1984]: Evaluation of mastic, a crude drug obtained from Pistacia Lentiscus for gastric and duodenal antiulcer activity. J Ethnopharmacol., 15 (3): 271-278.
- Gabr K.E. [1997]: Influence of indomethacin-mastic combinations on dissolution, absorption and gastroin- testinal mucosal damage in rats. Int. J. of Pharm., 158: 137–145.
- Huwez F.U., Thirlwell D., Cockayne A., Ala’Aldeen D.A.A. [1998]: Mastic Gum Kills Helicobacter pylori. N. Eng. J. of Med., 339 (26): 1946
- Marone P., Bono L., Leone E., Bona S., Carretto E., Perversi L. [2001]: Bactericidal activity of Pistacia Lentiscus mastic gum against Helicobacter pylori. J Chemother., 13 (6): pp 611-614.
- Bona S.G., Bono L., Daghetta L., Marone P. [2001]: Bactericidal activity of Pistacia Lentiscus gum mastic against Helicobacter pylori. The Am. J. of Gastroenterol., 96 (9) Supplement 1: S49.
- Roe I.H., Nam S.W., Myung N.H., Kim J.T., Shin J.H. [2003]: The effect of mastic gum on Helicobacter pylori-infected gastritis. Korean J. Gastroenterol., 41: 277-283.
- Heo C., Kim D.W., Do J.H. [2006]: Protective effects of mastic in non-steroidal anti-inflammatory drug induced gut damage and bacterial translocation in a rat model. Korean J. Med., 71: 354-361.
- Paraschos S., Magiatis P., Mitakou S., Petraki K., Kalliaropoulos A., Maragkoudakis P., Mentis A., Sgouras D., Skaltsounis A.-L. [2007]: In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob. Agents Chemother., 51 (2): 551–559.
- Kaliora A.C., Stathopoulou M.G., Triantafillidis J.K., Dedoussis G.V.Z., Andrikopoulos N.K. [2007]: Chios mastic treatment of patients with active Crohn’s disease. World J Gastroenterol., 13 (5): 748-753.
- Kaliora A.C., Stathopoulou M.G., Triantafillidis J.K., Dedoussis G.V.Z., Andrikopoulos N.K. [2007]: Alterations in the function of circulating mononuclear cells derived from patients with Crohn’s disease treated with mastic. World J Gastroenterol., 13(45): 6031-6036.
- Kottakis F., Lamari F., Matragkou C., Zachariadis G., Karamanos N., Choli-Papadopoulou T. [2007]: Arabino-Galactan proteins from Pistacia lentiscus var. chia: isolation, characterization and biological function. Amino Acids, 34: 413-420.
- Kottakis F., Kouzi-Koliakou K., Pendas S., Kountouras J., Choli-Papadopoulou T. [2009]: Effects of masticgum Pistacia lentiscus var. chia on innate cellular immune effectors. Eur. J. of Gastroenterol. & Hepatol., 21(2): 143-149.
- Hassan H.M.M. [2009]: Inhibitory Activities of Some Mucilages and Gums Against Certain Intestinal Disaccharidases. Austr. J. Basic & App. Sci., 3 (3): 2741-2746.
- Dabos K.J., Sfika E., Vlatta L.J., Giannikopoulos G. [2010]: The effect of mastic gum in Helicobacter pylori: A randomized study. Phytomedicine, 17 (3-4): 296-299.
- Dabos K.J., Sfika E., Vlatta L.J., Frantzi D., Amygdalos G.I., Giannikopoulos G. [2010]: Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial. J of Ethnopharmacology, 127 (2): 205–209.
- Gioxari A., Kaliora A.C., Papalois A., Agrogiannis G., Triantafillidis J.K., Andrikopoulos N.K. [2011]: Pistacia lentiscus resin regulates intestinal damage and inflammation in trinitrobenzene sulfonic acid-induced colitis. J. Med. Food, 14 (11): 1403-1411.
- Kountouras J., Zavos C., Deretzi G., Gavalas E., Chatzopoulos D., Katsinelos P., Tsiaousi E., Gagalis S., Polyzos S.A., Venizelos I. [2012]: Potential implications of Helicobacter pylori-related neutrophil-activating protein. World J. Gastroenterol., 18 (5): 489-490.
- Papalois A., Gioxari A., Kaliora A.C., Lymperopoulou A., Agrogiannis G., Papada E., Andrikopoulos N.K. [2012]: Chios mastic fractions in experimental colitis: implication of the nuclear factor κB pathway in cultured HT29 cells. J. Med. Food, 15 (11): 974-983.
- Miyamoto T., Okimoto T., Kuwano M. [2014]: Chemical composition of the essential oil of mastic gum and their antibacterial activity against drug-resistant Helicobacter pylori. Nat. Prod. Bioprospect., 4(4): 227–231.
- Papada E, Gioxari A, Amerik;anou C, Forbes A, Tzavara C, Smyrnioudis I, Kaliora AC, Regulation of Faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia Lentiscus) supplement: A double-bind and placebo-controlled randomized trial. Phytother Res. 2018 Nov. 18 doi:10.1002/ptr.6229.
- Papada E, Amerikanou C, Torović L, Kalogeropoulos N., Kaliora AC. Plasma free amino acid profile in quiescent Inflammatory Bowel Disease patients orally administered with Mastiha (Pistacia lentiscus); a randomised clinical trial. Phytomedicine, Volume 56, 15 March 2019, Pages 40-47.
- Watanabe H., Hagiwara S., Fukuda M., Yuichi I., Tamura N., Suzuki M., Kawasaki D., Fukahori M. [1973]: Double blind randomized control test for the usefulness of mastic compound dentifrice against periodontitis under using sonic toothbrush journal title. Yakuri To Chiryo, 38 (10): 915-925.
- Topitsoglou-Themeli V., Dangalis P., Lambrou D. [1984]: Chios Mastiha and oral hygiene I: A possible measure for decrease microbial plaque formation. Hell. Stom. Chron., 28: 166-170.
- Topitsoglou-Themeli V., Kolokotronis A., Dangalis P., Lambrou D. [1985]: Chios Mastiha and oral hygiene II: Differentiation in microbial plaque formation. Redodontia., 2: 56-59.
- Farella M., Bakke M., Michelotti A., Martina R. [2001]: Effects of prolonged gum chewing on pain and fatigue in human jaw muscles. Eur. J. Oral Sci., 109 (2): 81-85.
- Anastassiadou V., Siovas S. [2002]: Modulation of chewing rhythms to changes in viscoelasticity of chewing gums in people with different age and dental status. Stomatologia, 59 (1): 39-49.
- Takahashi K., Fukazawa M., Motohira H., Ochiai K., Nishikawa H., Miyata T. [2003]: A pilot study on antiplaque effects of mastic chewing gum in the oral cavity. J. Periodontol., 74 (4): 501-505.
- Aksoy A., Duran N., Koksal F. [2006]: In vitro and in vivo antimicrobial effects of mastic chewing gum against Streptococcus mutans and mutans streptococci. Arch. Oral Biol., 51 (6): 476-481.
- Sterer N. [2006]: Antimicrobial effect of mastic gum methanolic extract against Porphyromonas gingivalis. J. Med. Food, 9 (2): 290–292.
- Aksoy A., Duran N., Toroglu S., Koksal F. [2007]: Short-term effect of mastic gum on salivary concentrations of cariogenic bacteria in orthodontic patients. Angle Orthod., 77 (1):124-128.
- Biria M., Malekafzali B., Kamel V. [2009]: Comparison of the effect of xylitol gum- and mastic chewing on the remineralization rate of caries-like lesions. J. Dentistry, 6 (1): 6-10.
- Sakagami H., Kishino K., Kobayashi M., Hashimoto K., Iida S., Shimetani A., Nakamura Y., Takahashi K., Ikarashi T., Fukamachi H., Satoh K., Nakashima H., Shimizu T., Takeda K., Watanabe S., Nakamura W. [2009]: Selective antibacterial and apoptosis-modulating activities of mastic. In vivo, 23: 215-224.
- Al-Mofarji T., Al-Zahid N.R., Al-Hashimy E.H. [2013]: Antibacterial effect of mastic gum on aerobic oral bacteria. Iraqi Nat. J. Nurs. Spec., 26 (2): 136-140.
- Biria M., Eslami G., Taghipour E., Akbarzadeh Baghban A. [2014]: Effects of three mastic gums on the number of mutans streptococci, lactobacilli and pH of the saliva. J. Dent., 11 (6): 672-679.
- Lee B.Y., Lee K.H., Kim I.R., Kim Y.H., Park H.R., Park B.S. [2014]: The inhibition of oxidative stress by Chios gum mastic is associated with autophagy. Int. J. Oral Biol., 39 (2): 65-73.
- Karygianni L, Cecere M, Skaltsounis AL, Argyropoulou A, Hellwig E, Aligiannis N, Wittmer A, Al-Ahmad A.[2014]: High-level antimicrobial efficacy of representative Mediterranean natural plant extracts against oral microorganisms. Biomed Res Int., 839019
- Makaremi M, Zink K, de Brondeau F. [2016]: The importance of elevated masticatory forces on the stability of maxillary expansion. J Dentofacial Anom Orthod., 50:
- Koychev S, Dommisch H, Chen H, Pischon N. [2017]: Antimicrobial Effects of Mastic Extract Against Oral and Periodontal Pathogens. J Periodontol., 88: 511-517.
- Aspasia I. Tzani, Ilias P. Doulamis, Panagiotis S. Konstantopoulos, Ermioni D. Pasiou, Afrodite Daskalopoulou, Dimitrios C. Iliopoulos, Ioannis V. Georgiadis, Nikolaos Kavantzas, StavrowK. Kourkoulis, Despina N. Perea [2018]: Chios mastic gum decreases renin levels and ameliorates vascular remodeling in renovascular hypertensive rats. Biomedicine & Pharmacotherapy(2018) 899-906.
- Christos Kontogiannis, Georgios Georgiopoulos, Kostantinos Loukas, Eleni-Dimitra Papanagnou, Vasiliki K. Pachi, Ioanna Bakogianni, Ageliki Laina, Anastasios Kouzoupis, Kalliopi Karatzi, Ioannis P. Trougakos and kimon Stamatelopoulos [2018]. Chios mastic improves blood pressure haemodynamics in patients with aertial hypertension: impications for regulation of proteostatic pathways. european Journal of Preventing Cardiology 1-4
- Petersen R.K., Christensen K.B., Assimopoulou A.N., Fretté X., Papageorgiou V.P., Kristiansen K., Kouskoumvekaki I. [2011]: Pharmacophore-driven identification of PPARγ agonists from natural sources. J. Comput. Aided Mol. Des., 25 (2): 107-16.
- Vuorinen A., Seibert J., Papageorgiou V.P., Rollinger J.M., Odermatt A., Schuster D., Assimopoulou A.N. [2015]: Pistacia lentiscus oleoresin: Virtual screening and identification of masticadienonic and isomasticadienonic acids as inhibitors of 11β-hydroxysteroid dehydrogenase 1. Planta Med., 81 (6):525-532.
- Georgiadis I., Karatzas T, Korou L.-M., Agrogiannis G., Vlachos I.S., Pantopoulou A., Tzanetakou I.P., Katsilambros N., Perrea D.N. [2013]: Evaluation of chios mastic gum on lipid and glucose metabolism in diabetic mice. J Med Food, 00 (0): 1–7.
- Abdel-Ghaffar A.S., El Nawawy A.S., Mohamed M.S. [1957]: The inhibitory effect of mastic gum on bacterial growth. Alex. Med. J., 3: 119-124.
- Andrikopoulos N.K., Kaliora A.C., Assimopoulou A.N., Papapeorgiou V.P. [2002]: Biological activity of saliva against in vitro LDL oxidation after chewing commercial chewing gums. Ital. J. Food Sci., 14 (3): 279-288.
- Andrikopoulos N.K., Kaliora A.C., Assimopoulou A.N., Papapeorgiou V.P. [2003]: Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation. Phytother. Res., 17: 501–507.
- Dedoussis G.V.Z., Kaliora A.C., Psarras S., Chiou A., Mylona A., Papadopoulos N.G., Andrikopoulos N.K. [2004]: Antiatherogenic effect of Pistacia lentiscus via GSH restoration and downregulation of CD36 mRNA expression. Atherosclerosis, 174: 293–303.
- Assimopoulou A.N., Zlatanos S.N., Papageorgiou V.P. [2005]: Antioxidant activity of natural resins and bioactive triterpenes in oil substrates. Food Chemistry, 92: 721–727.
- Inducible NO synthase (iNOS) and cyclooxygenase (COX)-2.
- Zhou L., Satoh K., Takahashi K., Watanabe S., Nakamura W., Maki J., Hatano H., Takekawa F., Shimada C., Sakagami H. [2009]: Re-evaluation of anti-inflammatory activity of mastic using activated macrophages. In vivo, 23: 583-590.
- Mahmoudi M., Ebrahimzadeh M.A., Nabavi S.F., Hafezi S., Nabavi S.M., Eslami S. [2010]: Antiinflammatory and antioxidant activities of gum mastic. Eur. Rev. for Med. and Pharm. Sci., 14: 765-769.
- Qiao J., Li A., Jin X., Wang J. [2011]: Mastic alleviates allergic inflammation in asthmatic model mice by inhibiting recruitment of eosinophils. Am. J. Respir. Cell Mol. Biol., 45: 95–100.
- Triantafyllou A., Bikineyeva A., Dikalova A., Nazarewicz R., Lerakis S., Dikalov S. [2011]: Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress. Nutrition J., 10: 64-72.
- Quartu M., Serra M.P., Boi M., Pillolla G., Melis T., Poddighe L., Del Fiacco M., Falconieri D., Carta G., Murru E., Cordeddu L., Piras A., Collu M., Banni S. [2012]: Effect of acute administration of Pistacia lentiscus L. essential oil on rat cerebral cortex following transient bilateral common carotid artery occlusion. Lipids Health Dis., 11(8).
- Gortzi O., Athanasiadis V., Lalas S., Chinou I., Tsaknis J. [2014]: Study of antioxidant and antimicrobial activity of chios mastic gum fractions (neutral, acidic) before and after encapsulation in liposomes. J. Food Process. Technol., 5 (8): 355-359.
- Papada E, Gioxari A, Brieudes V, Amerikanou C, Halabalaki M, Skaltsounis AL, Smyrnioudis I, Kaliora AC. Bioavailability of Terpenes and Postprandial Effect on Human Antioxidant Potential. An Open-Label Study in Healthy Subjects. Mol Nutr Food Res. 2018; 62(3). doi: 10.1002/mnfr.201700751.
- Papada E, Torović L, Amerikanou C, Kalogeropoulos N, Smyrnioudis I, Kaliora AC. Modulation of Free Amino Acid Profile in Healthy Humans Administered with Mastiha Terpenes. An Open-Label Trial. Nutrients. 2018 Jun 3;10(6). pii: E715. doi: 10.3390/nu10060715.
- Katsanou E.S., Kyriakopoulou K., Emmanouil C., Fokialakis N., Skaltsounis A.L., Machera K. [2014]: Modulation of CYP1A1 and CYP1A2 hepatic enzymes after oral administration of Chios mastic gum to male Wistar rats. PLoS One., 9 (6): e100190.
- Saad Ur Rehman M., Hafeez Kamran S., Ahmad M., Akhtar U. [2015]: Anti-diabetic activity of crude Pistacia lentiscus in alloxan-induced diabetes in rats. Bangladesh J of Pharm, 10 (3):543-547.
- Tzani A, Georgiadis, I, Korou LM, Konstantopoulos P, Agrogiannis G, Vlachos I, Doulamis I, Katsilambros N, Perrea D. (2016). Investigation of chios mastic gum effect on metabolic profile in streptozotocin-induced diabetic mice. Atherosclerosis.
- Mikhail G.R., Selak L., Salo S. [1986]: Reinforcement of surgical adhesive strips. J Dermatol Surg Oncol., 12(9): 904-905, 908.
- Mikhail G.R., Selak L., Salo S., Balle M.R. [1989]: The efficacy of adhesives in the application of wound dressings. J Burn Care Rehabil., 10 (3): 216-219.
- Lesesne C.B. [1992]: The postoperative use of wound adhesives. Gum mastic versus benzoin, USP. J Dermatol Surg Oncol., 18 (11): 990.
- Ali-Shtayeh M.S., Abu Ghdeib S.I. [1999]: Antifungal activity of plant extracts against dermatophytes. Mycoses, 42: 665–672.
- Protopapa E.E., Heliou A., Tsigonia A., Kefala V., Triantafyllou A., Tsaknis J. [2001]: The antiphlogistic action of the Chios mastic essential oil: Treatment of skin irritations resulting from hair epilation and peeling with lotions containing mastic essential oil. Epitheorese Klinikes Farmakologias kai Farmakokinetikes, International Edition, 16: 203-205.
- Yavuzer R., Kelly C., Durrani N., Mittal V., Jackson I.T., Remine S. [2005]: Reinforcement of subcuticular continuous suture closure with surgical adhesive strips and gum mastic: Is there any additional strength provided? Am J Surg., 189 (3): 315-318.